Cystic Fibrosis Research Paper

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Such delivery would require efficient targeting at the cellular level to achieve a safe and effective...

more Gene therapy directed to the gastroenterological manifestations of cystic fibrosis (CF) would ideally be administered systemically.

There was no significant difference in body mass index (BMI) (18.7 /-3 kg/m2 versus 19.6 /-3 kg/m2, p=0.8). xylosoxidans-colonised patients did have more need for intravenous antibiotic treatment courses (19 versus 5, p<0.001); nevertheless, there was no significant difference in lung function decline over the study period (FVC: -6.25 /-12.34% versus -5.62 /-8.30%, p 0.77, FEV1: -5.62 /-8.30% versus -1.87 /-11.58%, p<0.47). xylosoxidans infection or colonisation is probably underestimated.

Colonised patients are mostly older, with more pronounced lung damage and lower lung function values.

The most affected areas are the lungs and digestive system....

[tags: Digestion, Cystic fibrosis, Pancreas, Cell] - The effects of cystic fibrosis can be broken down to a micro-perspective investigation in both the genotype, the encoding of the DNA, and the phenotype, the expression of DNA to trait.

Cystic fibrosis changes the cells that make mucus, sweat and digestive juices.

These fluids that are secreted are normally thin and slippery.

We compared deep-sequencing data of mycobiota and microbiota of 15 sputum samples from 5 cystic fibrosis (CF) patients with and without prior PMA-treatment of the DNA-extracts.

PMA-pretreatment had no significant effect on the entire and abundant bacterial community (genera expressed as operational taxonomic units (OTUs) with a relative abundance greater than or equal to 1%), but caused a significant difference in the intermediate community (less than 1%) when analyzing the alpha biodiversity Simpson index (p = 0.03).

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