Some important coumarin members have been isolated from microbial sources e.g. 6 Pharmacological activities: Antimicrobial activity: Coumarin derivatives are having promising antimicrobial activities as per recent literature survey, details of which have been presented as given below: Rama Ganesh by agar cup diffusion method.
DMF was used as blank, Streptomycin was used as anti-bacterial standard and Clotrimazole was used as anti-fungal standard drug at concentration of 1000μg/ml.
Ethyl 2-oxo-2H-chromene-3-carboxylate was prepared by cyclization of salicylaldehyde with diethylmalonate in presence of catalytic amount of piperidine.
Reaction of this ester compound with hydrazine hydrate in ethanol formed 2-oxo-2H-chromene-3-carbohydrazide.
some mannich base of 5-methyl-[(2-oxo-2H-chromen-3-yl) carbonyl]-2,4-dihydro-3H-pyrazol-3-one (Fig.
20) by using conventional and non conventional (microwave) techniques.The key intermediate was prepared by cyclization of compound with ethyl acetoacetate in presence of glacial acetic acid.The key intermediate pyrazolone considered as a cyclic amide and hydrogen atom attached to C4 atom should be appreciably labile to participate in the Mannich condensation.The one pot reaction preparation, spectral analysis, and molecular modeling experiments on the new 3,4-annelated coumarin systems with bioactivity associated structural features are described.These provided the insight into the equilibrium of the respective tautomeric forms making possible the reconciliation of previously published spectral data with the structure assignments as well as the correction of erroneously established structures.Activity of other compounds indicated that the presence of an additional fused benzene ring between the C-5` and C-6` positions inhibited the antibacterial activity towards ) compared to in Potato Dextrose Broth medium (PDB).Appropriate volumes of tested compounds were added to produce concentrations ranging from 10 to 100μg/m L. 12) and (Fig.13) showed good activity as antifungals compared to the antifungal ability of fluconazole, which was used as a standard drugs. 12 FIG.13 4-Heteroaryl-coumarin-3-carbaldehydes Streptomycin was used as standard anti-bacterial drug and ketoconazole was used as standard anti-fungal drug. 17) had activity equal to that of standard drug ketoconazole (31.25 μg/m L) against ntiinflammatory and analgesic activity: Parmar V et al synthesized 4-methyl coumarin derivatives 7,8-dihydroxy-3-ethoxycarbonyl methyl -4-methylcoumarin (DHEMC) and 7,8-diacetoxy-3 - ethoxycarbonylmethyl - 4 - methylcoumarin (DAEMC) (Fig.Coumarins have been under extensive studies for their versatile biodynamic activities, for example coumarins with phenolic hydroxyl group have the ability to scavenge reactive oxygen species and thus prevent the formation of 5- HETE and 5- HHT in arachadonic acid pathway of suppression of inflammation.Recent in vivo studies have revealed the role of coumarins in hepatotoxicity and also in depletion of cytochrome P450.Specifically, coumarin-3-sulfonamides and carboxamides were reported to exhibit selective cytotoxicity against mammalian cancer cell lines.The C4-substituted aryloxymethyl, arylaminomethyl, and dichloroacetamidomethyl coumarins, along with the corresponding 1-azacoumarins, have been demonstrated to be potential anti-microbial and anti-inflammatory agents.
Comments Thesis On Coumarins
New 3,4-Annelated Coumarin Derivatives Synthesis.
Annelated coumarin systems; Enamino and imino tautomeric forms;. p 23–25, PhD thesis, Univeristy of Helsinki, HelsinkiGoogle Scholar.…
Therapeutic Role of Coumarins and Coumarin-Related.
Coumarins are a group of polyphenolic compounds isolated. Nowadays, coumarins are also used as additives in. PhD Thesis, University.…
A Review of Coumarin Derivatives in Pharmacotherapy of.
Of particular interest in breast cancer chemotherapy, some coumarins and their active metabolite 7-hydroxycoumarin. Most reviews classify coumarins according to whether particular compounds are simple coumarins e.g. PhD thesis.…
Recent Advances in Transition-Metal-Catalyzed Synthesis of.
Priyanka et al. Review. Syn thesis. Recent Advances in Transition-Metal-Catalyzed Synthesis of. Coumarins. Priyanka. Rajesh Kumar Sharma.…
SYNTHESIS OF COUMARINS AND CHROMONES.
Thesis of compounds containing either the benzo-a-pyrone or the benzo-y-. reaction for the synthesis of coumarins Clayton? found that different phenols.…
COUMARINS AN OVERVIEW OF MEDICINAL CHEMISTRY.
Coumarins have attracted considerable attention of medicinal chemists and. PhD Thesis, Dublin City University, Dublin, Ireland, 1999.…
Synthesis of Novel Fatty Substituted 4-methyl-2HChromen-2.
Coumarins and their derivatives have made these couma- rins interesting. which involved the syn- thesis of 7-hydroxy-4-methyl-2H-chromen-2-one by react-.…
Ring-closing-metathesis-based synthesis of annellated.
Ring-closing-metathesis-based synthesis of annellated coumarins from 8-allylcoumarins. Christiane Schultze and Bernd Schmidt*.…
Synthesis of coumarins by ring-closing metathesis* - De Gruyter
This method allows for convenient access to a variety of coumarins substituted. thesis by ring-opening metathesis polymerizations ROMP 1 and step-growth.…